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                <text>Menurut data WHO (2023), cakupan imunisasi DPT global mengalami penurunan akibat dampak pandemi COVID-19. Sekitar 25 juta anak di seluruh dunia belum menerima imunisasi DPT lengkap pada tahun 2022, yang merupakan angka tertinggi dalam satu dekade terakhir. Sementara itu, Profil Kesehatan Indonesia Tahun 2023 mencatat bahwa cakupan imunisasi DPT-HB-Hib dosis lengkap (tiga kali) baru mencapai 85,3%, masih di bawah target nasional sebesar 95% (WHO, 2023). Pemberian kompres hangat pada bayi yang mendapatkan penyuntikan Imunisasi DPT, dapat menimbulkan efek hangat serta nyaman dan tenang, berupa sentuhan yang dapat menyebabkan terlepasnya endorphin, sehingga memblok transmisi stimulus nyeri, dan dapat juga mengurangi kemerahan dan bengkak pada tempat penyuntikan imunisa DPT. (Runiari&amp;Surinati 2012) Tujuan Penelitian ini adalah Untuk menganalisis Pengaruh Terapi Kompres Hangat Pada Tempat Penyuntikan Terhadap Nyeri Pada Bayi Saat Imunisasi DPT Combo di PMB Pera Kecamatan Medan Tuntungan Kota Medan. Jenis penelitian ini adalah penelitian quasi eksperimental dengan menggunakan pendekatan Posttest only control group design yaitu untuk mengetahui pengaruh terapi kompres hangat pada tempat penyuntikan terhadap respon nyeri pada bayi saat imunisasi DPT Combo. Populasi dalam penelitian ini yang akan digunakan adalah 40 bayi (20 bayi untuk kelompok ekperimen dan 20 bayi untuk kelompok kontrol) dengan Teknik sampling yang digunakan adalah teknik non probability sampling dengan pendekatan purposive sampling. Instrumen penelitian berupa kuesioner tertutup yang telah diuji validitas dan reliabilitasnya Data dianalisis menggunakan uji statistic uji Korogorov Smirnov untuk menentukan distribusi data. Sedangkan untuk membandingkan kelompok kompres hangat dengan kelompok kontrol menggunakan uji Mann-Whitney. Berdasarkan Hasil analisis data dengan ujin Mann Whitney Test diperoleh nilai Symp.sig 0,0000,05 berarti Ho ditolak. Maka dapat disimpulkan bahwa ada pengaruh yang sidnifikan antara terapi kompres hangat pada tempat penyuntikan saat imunisasi DPT Combo terhadap respon nyeri pada bayi di PMB Pera Kec. Medan Tuntungan Kota Medan Provinsi Sumatera Utara Tahun 2025.</text>
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